When I take my babies to routine checkups due to their constant physical changes, comparisons like Similac Advance vs 360 suddenlymatter more than ever before.
I question whether I am giving them the right formula or not. Are these Similac formulas able to give proper nutrients to my infants?
Before choosing which one is best for our infant, we should thoroughly know about these differences. Similac 360 total care is best designed to mimic the breast milk’s nutrition, which makes feeding an easy task without neglecting natural flavours.
On the other hand, Similac Advance is known as a premium formula that provides all the necessary nutrition in the first year after birth. Now we wonder between Similac Advance Vs 360 which is better?
Here, in this guide, I will help you through the tough choice between Similac Advance vs 360 Total Care for a healthy infant. Their health and life are sensitive, which needs to be dealt with care for healthy growth.
What is Similac Advance?

Initially, Similac Advance is designed for infants from 0 to 12 months, depending on how long they need it. Some people are switching from Similac 360 to Similac Advance without actually knowing about them.
This formula is a premium version of the standard formula that provides daily nutrients to the baby without any allergies or critical digestive issues.
It is rich in DHA, ARA and iron that develop the brain and eyes. You will find this formula in stage 1 and stage 2 as your infant grows from newborn to follow-up.
Similac Advance is made up of whey and casein protein which is easily digested. The vitamins, including A, C and E will support the immune system.
If you are a regular like me, then you’ll notice the smooth consistency in stool and no stomach issues anymore. This formula is affordable and balanced, but if your infant suffers from allergies or other sensitivities, then avoid this formula for wellbeing.
What is Similac 360 Total Care?

Furthermore, Similac 360 Total Care is designed to replicate breast milk properties.
As I said before, it is a milk-based formula that contains 5 HMOs that work efficiently for immunity, brain development and digestive health. Similac 360 has other nutrients like lactose, iron, calcium and zinc for physical growth and strength.
It is also found in other variants like Similac 360 Total Care Sensitive, Similac Sensitive Ready-to-Feed and Toddler Starter versions. They are easy to digest and reduce the effect of gas, fussiness and hard stools.
Similac 360 is best for newborns to 12 months and if you want an extra energetic formula for an infant. You should avoid it if your baby suffers from galactosemia.
Most importantly, I highly recommend to please consult a paediatrician before switching to any formula. As per research, it is the closest to breast milk that contains healthy fats like omega fatty acids and so on.
Key Differences Between Similac Advance Vs 360

There is a visible difference between Similac Advance vs 360 Total Care that makes a distinction. They both have prebiotics and other essential nutrients from breast milk.
Choosing the best formula for an infant is a hard choice when both of them are healthy and immunity-supporting. I have discussed some key differences to make the decision easy for you.
Core Formula
Their core formula is unique and standardised according to the needs of an infant. The Similac Advance is a nutritional formula that gives all the vital nutrients like vitamins, minerals, DHA and proteins.
It makes an infant healthy and improves the digestive system, physical growth and mental advancements.
On the flip side, the Similac 360 total care is not only a functional formula but also a nutritional change in the diet. It has 5 HMO prebiotics, which are found naturally in breast milk.
Nutrition
Similac Advance and Similac 360 Total Care are both rich in nutrients, including protein, fat and carbohydrates. With some similar features, there are other unique nutrients to create a difference.
In Similac Advance, it is rich in vitamins ( A, C, E ), choline, omega fatty acids and is a balanced milk-based formula.
In contrast, Similac 360 Total Care has enhanced nutrition with added prebiotics and advanced gut support for an infant. They both have nutrients that are healthy and advanced.
Digestibility
While Similac Advance is a normal digest as it contains whey and casein protein, Similac 360 is the easiest to digest with processed protein and carbohydrate.
Feeding Similac Advance will also be tolerable for an infant’s gut health and will result in minimal gas or fussiness. Conversely, Similac 360 is the easiest with advanced 5 HMO prebiotics for an unbothered gut health of an infant.
It is perfect for a sensitive baby who often suffers from fuzziness and other digestive issues.
Price
In terms of price, Similac Advance is an affordable choice as it is given on a daily basis to an infant. It will fall under your budget with an average price of $20 to $40 as it provides essential nutrients in the form of a formula.
On the other side, Similac 360 Total Care is higher in cost due to the high amount of prebiotics, which is known to be the premium like breast milk. It has numerous healthy nutrients for an infant.
Main Purpose
When it comes to the main purpose, they are used for alternative purposes. A Similac Advance offers essential nutrition for the consistent growth of an infant with standardised minerals and vitamins.
They strengthen gut health and vital DHA contributes to the steady development of the brain and eyes.
Contrarily, Similac Total Care is used most for enhancing gut health and giving nutrition similar to breast milk. It gives a premium feeling to the parents who prefer to give nutrients naturally.
| Basis | Similac Advance | Similac 360 Total Care |
| Core Formula | Milk-based nutritional formula | Premium formula based on breast milk’s nutrients |
| Nutrition | Balanced nutrients, including vitamins, fat, minerals and DHA | With the same base and added 5 HMOs prebiotics for the easiest digestion |
| Digestibility | Normally digested and easy on gut health | Easily digested and highly tolerable for infants with stomach issues |
| Price | Affordable for everyday uses | Higher price due to the added prebiotics |
| Main purpose | Used to provide essential nutrients for a normal infant | Premium to parents as it is good for immunity and digestion. |
Which One Should You Choose?
Choosing the formula for the baby is not a hard task if you are aware of the requirements. The main purpose is something that makes the choice between Similac Advance Vs 360 difficult.
I have been through the main differences to ease the choice for parents. They may look similar and belong to the group of Similac products, but they are used for distinctive reasons.
If you are going for Similac Advance, then it is a great choice for an already healthy infant that requires daily essential nutrients for healthy growth. There are many reasons why to choose Advance as it is also affordable to most parents and is easy to digest.
It is designed with the simplest formula with minimal added components, including whey and casein protein, vitamins and fats. To switch on this formula, you should definitely consult a paediatrician for medical guidance.
In the case of Similac 360 Total Care, most parents opt for this premium choice of formula that contains 5 HMOs prebiotics to replicate the nutrients present in natural breast milk. This formula is designed to suit the gut of an infant.
To be precise, you should choose this as it has almost all nutrients. It can be out of budget for some people, but for extra benefits, it is a relevant choice.
You are open to sticking to the advance, but if you have no budget issue or still have constipation issues, then switching to 360 Total Care is a good option.
Similac Advance Vs. 360 Reddit Reviews
When I was looking over Similac Advance vs 360 Reddit reviews, I found some comments to help you decide. They both are known to help with digestion and other health issues collectively. Yet, they are suggested only by paediatricians as they may have side effects. Here, I mentioned a comment for you in the given comparison.
One of the Reddit users commented, 360 has 5 HMOs and Advance has none, and those HMOs can really help keep the GI tract moving. Baby probably just had an easier time digesting 360. He meant that Similac 360 is a better choice for digestion than Advance. Later, in next line he also said that if you are financially restricted, then you can adjust with Similac Advance but there could be possible consequences.
In another reddit commented that “I switched from Similac Advanced to 360 Total Care, and my baby seems happier! The extra nutrients must be helping.” Here, the user seemed satisfied with the positive effects on an infant.
Such comments on Similac Advance vs 360 total care Reddit reviews make it not so tough because Similac 360 is better in many ways than Similac Advance. Even though you are considering a person’s advice, still make sure to take proper guidance from an expert paediatrician to prevent possible risks.
Conclusion
After all the comparisons of Similac Advance vs 360 Total Care, the choice has been simplified for most parents. As a concerned parent, I was making sure that the formula I am giving to my infant was good enough or not.
Initially, in this guide, we learned about the key differences between Similac Advance and Similac 360 Total Care. Similac Advance is used as a balanced nutritional formula that falls under the budget.
It has numerous base nutrients like protein, vitamins and fat for growth and consistent development of the brain and eyes.
If we consider Similac 360 total care, it is known to be the premium baby formula that mimics the natural properties of breast milk. It has 5 HBOs prebiotics that contribute highly to the enhanced growth of an infant. It is considered much better than Similac Advance in nutritional properties.
In the end, choosing the baby formula between Similac Advance vs 360 can completely change the health of an infant.
It can be healthy or have possible side effects. You should consult a paediatrician before switching to formula in any case.
